Our research has determined that aging is largely controlled by nine (9) primary internal biological factors, now understood to be reversible. Here they are listed hierarchically, most important to least important:

 

1. Pineal clock- (Pineal / Hypothalmic/ Pituitary/ Superchiasmatic Nucleolus (SCN)  axis) this is the master time clock and coordinates the body's circadian rhythm and the time-cycled release of melatonin and other critical hormones and neurotransmitters.

2. Thymic involution- immune depletion, and T-cell diminution.

3. Blood signaling and transcription factors- reverse distributed blood signaling of TGF-ß1 and Oxytocin (to all cells).

4. Telomere length- Attrition of the protective chromosomal endcaps causing programmed Cellular senescence.

5. Senolytics- (autophagy, mitophagy) Accumulation of senescent zombie-like cells that inflame and signal senescence to healthy cells.

6. Inflammaging- Inflammatory response, altered intercellular communication and the production of inflammatory cytokine and chemokine molecules.

7. Stem Cell Exhaustion- loss of source stem cells.

8. Cellular Metabolic Efficiency (NAD, NMN, NR, Sirtuins, Resveratrol, ATP, ROS)- Energy production and mitochondrial dysfunction.

9. Epigenetic clock (DNAm cytosine methylation)- Alterations to the epigenome that control which genes are turned on and off.

 

• Two factors are endocrinological: Pineal/ Hypothalamic /Pituitary/ SCN axis, and Thymus involution, which are internal aging-clock related.

• Two factors are DNA based: Telomere length and Epigenetic DNA methylation, which are internal aging-clock related.

• Two factors are cellular: Cellular Metabolic Efficiency and Senolytics, and are adapted systemic responses. 

• Three factors are Systemic: Blood signaling, and Stem Cell Exhaustion, which are internal aging-clock related and Inflammaging, which is an adapted systemic response.

​

In order to address these conditions of aging Extended Longevity has developed nine (9) synergistic and mimetic biologic formulations.  They include:

​

1. Pinetonal™ - is a Pineal Gland supporting formulation of six (6) plant species known to increase melatonin, pineol, zinc, and selenium, included are phytotherapeutic extracts of Pistacia vera, Scutellaria baicalensis, Passiflora incarnata, Panax quinquefolius, Elitaria cardamomum, and Cinnamomum verum.

2. Thyvolve™ - is designed for regenerating the Thymus Gland and reversing the age-dependent process of Thymus involution. It consists of six (6) phytotherapeutic extracts including Selaginella involvens, Pinus sylvestris (Pollen), Curcuma longa, Zingiber officinale, Elitaria cardamomum, and Cinnamomum verum. 

3. Bluecosig™ - Bluecosig Formula is designed for blood signaling and transcription adjustment, for aging reversal or rejuvenation via blood signaling to all cells. It contains phytotherapeutic extracts of Caulophyllum thalictroides, Panax quinquefolius, Scutellaria baicalensis, and Curcuma longa.

4. Telogenic™ - Telogenic Longevity Formula is a phytotherapeutic extract of three (3) synergistic herbal analogs, including Astragalus membranaceus, Centella asiatica, and Salix Alba.  It is a telomerase-creating natural plant extract that stops the degradation of telomeres and rebuilds them, reversing cell loss from telomere attrition. 

5. Sentophagy™ - is a phytotherapeutic extraction of five (5) plant species known to induce autophagy and mitophagy, including Taraxacum officinale, Camellia senensis, Berberis vulgarus, Curcuma longa, and Cinnamomum verum.

6. Inflasolve™ - is formulated to reduce systemic inflammation that is a root cause of aging (called “Inflammaging”).  It contains phytotherapeutic extracts of Curcuma longa, Boswellia sacra, Salix alba, Camellia sinensis, and Cinnamomum verum.

7. Stemegenis™ - is designed to regenerate active stem cells from the age-dependent condition called “stem cell exhaustion,” reversing it.  It contains phytotherapeutic extracts of Garcinia indica, Astragalus membracanus, and Cinnamomum verum.

8. CMEnhance™ - is designed to support Cellular Metabolic Efficiency, increasing Resveratrol, Sirtuins, NAD, NMN and contains phytotherapeutic extracts of Polygonum cuspidatum, Scutellaria baicalensis, Tabebuia avellanedae, Curcuma longa, and Cinnamomum verum.

9. Epiverse™ - is an Epigenetic Clock reversing (DNAm, cytosine methylation) synergistic herbal analog formulation of six (6) plant species. Included are phytotherapeutic extracts of Berberis vulgaris, Pinus sylvestris (Pollen), Lepidium meyenii, Taraxacum officinale, Elitaria cardamomum, and Cinnamomum verum.

​

Rejuvenation and the reversal of the aging process is a slow, steady process that requires patience and perseverance, like watching grass grow.  In some instances, there will be remarkable transformations. Otherwise, as it has taken many years to ripen our physical maturity, so it will rejuvenate in the fullness of time.

​

In order to initiate a reversal of the nine (9) conditions of aging and to effect a cellular and systemic bodily rejuvenation, it is the opinion of Extended Longevity that 1-2 ml of each of these nine (9) Phytotherapeutic  Formulations should be taken every day, in the mornings, before taking food, with the exception of Pinetonal, which should be taken before bed.